Review Article DEADLY INFLAMMATORY CYTOKINE STORM AS IMMUNE RESPONSE IN COVID-19 PATIENTS

Abstract

Coronavirus disease 2019 (COVID-19) outbreak which is caused by infection with SARS-CoV-2 was declared as a massive threat to international health by WHO in March’2020. This SARS-CoV-2 infection leads to immune reactions in the host known as cytokine storm, dysregulation in the host immune system leading to uncontrolled release of cytokines. Several clinical studies emphasize pertinent changes occurring in both innate and adaptive immune systems of the human body in response to SARS-CoV-2. As the world must live amidst the current ongoing virus, understanding the immunology of the disease can assist in disease containment and the development of more effective vaccines and therapeutics to prevent and treat patients infected with COVID-19. Here, we have discussed the changes in the host immune response to infection by SARS-CoV-2, mechanism of cytokine storm & association of other major cytokines.