Original Articles NEPHROPROTECTIVE EFFECT OF METHANOLIC EXTRACT OF DINOTHROMBIUM TINCTORIUM IN ALBINO RATS
Keywords:
Urea, Creatinine, MedicineAbstract
Modern world has proven scientifically that medicines derived from animals are important tools in treating ailments today.
Objective:
In current project, goal was to estimate the nephro-protective effects of methanolic extract of Dinothrombium tinctorium against carbon tetrachloride-induced nephrotoxicity.
Study design:
It was a randomised control study.
Methodology:
Aqueous methanolic extract (70% v/v) of Dinothrombium tinctorium (Dt.Cr) was arranged followed by subsequent evaporations. Renal toxicity was induced by CCl4 (2 ml/kg, p.o) in paraffin oil on 7th day of experiment. Administration of methanolic extract of Dinothrombium tinctorium (300mg/kg body weight/day) orally sheltered the CCl4 caused elevation of renal serum markers that include urea and creatinine. There was renal markers elevation in the CCl4 alone treated animals.
Results:
Administration of methanolic extract to CCl4 encounter protection against the renal toxicity.
Conclusion:
The findings thus suggested that this methanolic extract can be used as nephroprotective agent against CCl4-induced renal toxicity in albino rats.
![Journal of Akhtar Saeed Medical & Dental College](https://amdc.edu.pk/Ojs/ojs-3.3/public/journals/2/article_37_cover_en_US.jpg)