Original Articles NEPHROPROTECTIVE EFFECT OF METHANOLIC EXTRACT OF DINOTHROMBIUM TINCTORIUM IN ALBINO RATS

Abstract

Modern world has proven scientifically that medicines derived from animals are important tools in treating ailments today.

Objective:

In current project, goal was to estimate the nephro-protective effects of methanolic extract of Dinothrombium tinctorium against carbon tetrachloride-induced nephrotoxicity.

Study design:

It was a randomised control study.

Methodology:

Aqueous methanolic extract (70% v/v) of Dinothrombium tinctorium (Dt.Cr) was arranged followed by subsequent evaporations. Renal toxicity was induced by CCl4 (2 ml/kg, p.o) in paraffin oil on 7th day of experiment. Administration of methanolic extract of Dinothrombium tinctorium (300mg/kg body weight/day) orally sheltered the CCl4 caused elevation of renal serum markers that include urea and creatinine. There was renal markers elevation in the CCl4 alone treated animals.

Results:

Administration of methanolic extract to CCl4 encounter protection against the renal toxicity.

Conclusion:

The findings thus suggested that this methanolic extract can be used as nephroprotective agent against CCl4-induced renal toxicity in albino rats.