Original Article TO COMPARE THE EFFICACY OF HYBRID THERAPY VERSUS CONVENTIONAL TRIPLE REGIMEN IN HELICOBACTER PYLORI INDUCED GASTRITIS

Abstract

Objective: To compare the efficacy of Hybrid therapy versus conventional triple regimen in H.pylori induced gastritis

Material and methods: It was a Randomized control trial 170 patients fulfilling the selection criteria were enrolled in the study from OPD of Hijaz hospital Lahore and from the Department of Gastroenterology, Jinnah Hospital Lahore. 85 cases were given Hybrid therapy (Group-A) and 85 cases were given conventional triple regimen (Group-B). Informed consent was obtained. Demographic information (name, age, and sex) were taken. The mean age was 40.43 ± 17.01 years in the Hybrid therapy group and 42.99 ± 12.98 years in the conventional triple regimen group. In group A, 62% cases had ages less than 45 years, and 37.6% of cases had age 45 years or above.   In group B, 68.2% cases had an age less than 45 years and 31.8% of cases had an age of 45 years and above.  In group A, 50.6% cases were male and 49.4% cases were female.  In group B, 72.9% cases were male and 27.1% cases were female. In group A, 58.8%, 22.4%, and 18.8% of cases had low, middle and high socioeconomic status respectively. In group B, 57.6%, 29.4 and 13% of cases had low, middle and high socioeconomic status respectively.

In the Hybrid therapy group, eradication was achieved in 91.8%. In conventional triple regimen, eradication was achieved in 62.4% cases (p-value=0.00).

Conclusions: Eradication achievement was significantly more common with Hybrid therapy as compared to the conventional triple regimen. Hybrid therapy was significantly more effective than the conventional triple regimen in all age groups, both genders and all socioeconomic groups.