Original Articles COMPARISON OF DETEMIR VERSUS NEUTRAL PROTAMINE HAGEDORN FOR MANAGEMENT OF FEMALES PRESENTING WITH DIABETES DURING PREGNANCY.

Abstract

Background:
Gestational diabetes mellitus (GDM) is the type of diabetes, first diagnosed during pregnancy. Increased Body mass index (BMI), previous history of gestational diabetes, family history of type II diabetes and polycystic ovarian syndrome are risk factors for the development of gestational diabetes mellitus. Gestational diabetes resolves after pregnancy in most cases. The main objective of the study was to compare the efficacy with Detemir versus Neutral Protamine Hagedorn for management of pregnant females presenting with gestational diabetes.

Material and Methods:
A randomized Control Trial was carried out in obstetrics & gynecology department, Unit I, Services Hospital, Lahore for 6 months from 05-04-2018 to 05-10-2018. Total of 710 females were inducted into study. Then participants of study were divided into two groups. Then
females were advised to take one shot daily at same time and followed-up till 36 weeks. Reports were assessed and level of HbA1c was noted. If HbA1c<6.0%, the efficacy labeled. SPSS version 20 was used to analyze all the collected data.

Results:
The mean age of participants in Detemir group was 29.25±6.14 years whereas in the NPH group was 29.97±5.97 years. Efficacy was achieved in 267 cases (175 with determine vs. 92 with NPH, p-value=0.001).

Conclusion:
Detemir is significantly more effective than NPH for management of pregnant females presenting with gestational diabetes.