Orignal Article Effect of hyperlipidemia on fertility parameters in male albino rats
Abstract
ABSTRACT
Background: Both industrialized and developing nations are experiencing an increase in lipid metabolic problems brought on by poor eating practices, which have an adverse effect on sperm quality and quantity. The oxidative stress, one of the most significant factors affecting the male gametes and linked to infertility, is a general characteristic of hyperlipidemia. This study aimed to determine the effects of a high fat diet on serum testosterone levels, sperm count and sperm motility in male albino rats.
Material and Methods: In this randomized control trial, 60 male albino rats were classified into two groups (groups A and B). Group A was a control group, and hyperlipidemia was induced in group B rats by adding 1% cholesterol and 15% palm oil to standard chow for four weeks. After four weeks, blood was taken through cardiac puncture for lipid profile and serum testosterone levels measurement. Semen was collected from cauda epididymis for sperm count and sperm motility. Data were analyzed by using SPSS version 20.
Results: In hyperlipidemic rats, serum testosterone, sperm count and sperm motility were significantly decreased with p-value= 0.03, 0.001, 0.028 respectively, compared to group A rats.
Conclusion: Decrease in testosterone, sperm count and motility after hyperlipidemia indicates its negative effects on male fertility
