Original Articles EFFECT OF ETHANOLIC EXTRACT OF CLOVE (Eugenia Caryophyllata) ON PAIN IN MICE

Abstract

Background:

Pain is a natural phenomenon. There are several pharmacological medicines available in the market for pain relief. Ethanolic extract of clove is a natural ingredient and can be as beneficial as a pharmacological drug for pain relief.

Objective: To determine the effect of Eugenia caryophyllata flower buds ethanolic extract on experimentally induced pain in albino mice.

Material and Methods:

This randomized trial was done on 90 male albino mice. An intraperitoneal injection of 0.6% acetic acid was induced for the writhing test as a chemical model of nociception. Mice were divided randomly into three equal groups. Group A was considered as a control group (n=30) and normal saline was infused; group B was given Eugenia caryophyllata flower bud ethanolic extract (n=30) and group C was given an intraperitoneal injection of indomethacin (n=30). In these mice, abdominal contractions (writhings) were counted. SPSS version. 22 was used to analyze the data.

Result:

The mean number of writhing in each of the three groups of mice was 16.80 writhings in group A, 4.90 writhings in group B, and 4.60 writhings in group C. Ethanolic extract of clove and indomethacin significantly reduced (p<0.05) the number of writhing.

Conclusion:

The Eugenia caryophyllata ethanolic extract significantly reduces the pain in mice. This analgesic effect is almost similar to that produced by indomethacin